People speak of Prozac as being the dawn of anti-depressants, or if not that, the first anti-depressant that really worked, but in reality anti-depressants have been around since before the fifties, even Benedril was shown to have anti-depressant properties.
The most effective medicine in curing depression to date, Imipramine, was invented in the fifties. Imipramine is often used as the 'Gold Standard' against which other anti-depressants are measured against. It is rarely still prescribed today, except when other more modern medicines fail.
Where Prozac stands out is it was the first of its class of drug SSRI, which, while perhaps less effective, also has far less side effects, and isn't as easy to intentionally kill oneself by overdose.
I find this sort of information fascinating, and am sometimes surprised when reading books and articles how few people,, even sometimes doctors seem to be aware of this. It is interesting how something seem to become forgotten by the general culture.
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